产品货号:
Z23072
中文名称:
OTUD5抗体
英文名称:
Anti-OTUD5 Antibody
产品规格:
0.1mg
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-OTUD5 Antibody |
指标别名 | DUBA;OTU domain-containing protein 5;Deubiquitinating enzyme A;DUBA |
克隆性 | Polyclonal |
检验物种 | human,mouse,rat |
应用范围 | ELISA,WB,IHC,IF |
基因名称 | OTUD5 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | OTUD5 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human OTUD5.The immunogen is located within amino acids 400 - 450 of OTUD5. |
计算分子量 | 61kDa |
成分 | OTUD5 Antibody is supplied in PBS containing 0.02% sodium azide. |
纯化方式 | OTUD5 Antibody is affinity chromatography purified via peptide column. |
浓度 | 1mg/mL |
产品形态 | 溶液 |
保存条件 | 4℃可保存3个月,-20℃可保存1年。 |
背景资料 | OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily.The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3,an essential type I interferon adaptor protein.Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade,indicating that OTUD5 acts as a negative regulator of innate immune responses.It has been suggested that by suppressing IFN-I production,OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus.Multiple isoforms of OTUD5 are known to exist. |
Uniprot ID | Q96G74 |
基因名全称 | OTU domain containing 5 |
蛋白名全称 | OTU domain containing 5 |
推荐稀释比 | OTUD5 antibody can be used for detection of OTUD5 by Western blot at 1 ~ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in mouse samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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